Biomedicine. Lowering LDL--not only how low, but how long?
نویسندگان
چکیده
منابع مشابه
A Century of Cholesterol and Coronaries: From Plaques to Genes to Statins
One-fourth of all deaths in industrialized countries result from coronary heart disease. A century of research has revealed the essential causative agent: cholesterol-carrying low-density lipoprotein (LDL). LDL is controlled by specific receptors (LDLRs) in liver that remove it from blood. Mutations that eliminate LDLRs raise LDL and cause heart attacks in childhood, whereas mutations that rais...
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Arteriosclerotic vascular disease manifests as heart disease, stroke, aortic aneurysms, and peripheral vascular disease, and is a growing problem world-wide. The preventive efforts made so far have demonstrated that lowering LDL-C is one action that individuals and populations can do with significant success in delaying the onset of clinical events. Epidemiological studies and small clinical tr...
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BACKGROUND Comprehensive management of diabetes should include management of its comorbid conditions, especially cardiovascular complications, which are the leading cause of morbidity and mortality among patients with diabetes. Dyslipidemia is a comorbid condition of diabetes and a risk factor for cardiovascular complications. Therefore, lipid level management is a key of managing patients with...
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Lifelong exposure to raised concentrations of LDL cholesterol increases cardiovascular event rates, and the use of statin therapy as an adjunct to diet, exercise, and smoking cessation has proven highly effective in reducing the population burden associated with hyperlipidaemia. Yet, despite consistent biological, genetic, and epidemiological data, and evidence from randomised trials, there is ...
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I n the past several months, a remarkable transformation occurred in how the field regards lipoproteins, statins, and atherosclerosis. The straw—or tree trunk—that broke this stubborn camel's back was the prospective, randomized, double-blinded Improved Reduction of Outcomes: Vytorin Efficacy International Trial (IMPROVE-IT). 1 This key study demonstrated that lowering plasma low-density lipopr...
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ورودعنوان ژورنال:
- Science
دوره 311 5768 شماره
صفحات -
تاریخ انتشار 2006